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[4] [7] Berberine should also be avoided during pregnancy and breastfeeding

second, in low-risk patients, hematocrit control is easily achieved with drug-free phlebotomy and if an alternative to phlebotomy is needed, for one reason or another, peg-IFN offers a more attractive option since it also controls thrombocytosis, leukocytosis, splenomegaly, and certain symptoms such as aquagenic pruritus